After returning from Latveria, Reed and Sue seek out a peaceful residence in which to begin to raise the baby. Strange things begin to occur when they choose a mysterious but tranquil house in the country...
Reed and Johnny desperately search for clues to the whereabouts of the Thing, who has been taken to the planet Kral by his Skrull captor. There Ben must face a barbaric and bloodthirsty society, reminiscent of prohibition era Earth.
Believing it will be safer for an infant away from the Baxter Building, the Fantastic Four take a trip upstate to deliver their new son (who's name is revealed, finally) to Agatha Harkness. When they arrive, a storm kicks up and they stay the night. Then, the Frightful Four come out to play.
While on an outing, the Fantastic Four investigate multiple attacks on ships from a man shaped monster. As the team begins to search caves beneath the waves, their guide destroys the ship and leaves them stranded without oxygen.
The Maggia attempt to dispose of the Fantastic Four so they can take all of Reed's inventions. After being dumped in the harbor and encased in coffins, can the super hero team survive and mount a counter attack on the Baxter Building?
Namor discovers Magneto and saves him from a winged reptile before returning with the mutant to Atlantis. As the Fantastic Four come under siege, they trace magnet waves to the Realm Eternal. When an attack goes too far, Ben fires a missile towards the undersea kingdom, creating a chain reaction that could result in war.
Reed restarts attempts to cure Ben of his condition and succeeds, but with terrible consequences. Ben begins behaving in an increasingly cruel and mean-spirited way to those he loves. Meanwhile, a crazed man named Janus demands that Reed allow him into the Negative Zone for a mysterious purpose.
Reed is trapped in the Negative zone with a destructive natural force on one side and an army built by Annihilus on the other. As Reed tries to devise a plan, he receives some help from the other side of the gateway to Earth.
Johnny discovers that Maximus is once again the ruler of the Great Refuge. More importantly, he learns that Crystal's journey with Lockjaw has been interrupted and he'll stop at nothing to discover her whereabouts.
With the Thing and Medusa captured only Reed now stands to defend the Baxter Building from the Frightful Four. But who is Thundra, the newest member of this sinister cohort, and what are her true motives? Meanwhile, Johnny Storm finds that things are not as they seem in the Great Refuge.
A strange summons brings the FF to Whisper Hill where they find Agatha Harkness and her mansion missing. Meanwhile someone has found the whereabouts of Sue and Franklin and has sent Dragon Man to recover them.
Pietro "Quicksilver" Maximoff and Princess Crystal of the Inhumans do cordially invite you to celebrate the occasion of their union in holy matrimony. Please come prepared for fine food, better company, and a good old fashioned melee.
Ghost Rider and The Thing find a peculiar mystery in the desert, after they are summoned to a southwest reservation by strange lights in the sky. It'll take more than a miracle for the pair to emerge unscathed.
Johnny Storm and an alternate Earth Reed Richards team up to fight Arkon, architect of the three-worlds-war. Meanwhile, Ben fights a desperate battle against Gaard, the guardian of the nexus that supplies Arkon's world with energy.