Doctor Otto Octavious, a brilliant atomic scientist, is caught in an explosion when one of his experiments goes wrong, causing his brain damage and the mechanical arm apparatus he was wearing to fuse to his vertebrae. The demented Doctor still strives to carry on with his experiments and no one will stop him. Not even Spider-man!
After serving his prison term Doctor Otto Octavius has been released! Meanwhile Peter Parker is dealing with his feelings over the disappearance of Betty Brant. Will this affect him as Spider-man when he may have to stop Doctor Octopus for the second time?!
Doctor Octopus escaped from Spider-man in Philadelphia and has been on a crime spree ever since. Finally returning to New York to confront his nemesis, he kidnaps Betty Brant and uses her as bait to get a confrontation with the amazing Spider-man!
Doctor Octopus has escaped from prison and gathered together Elektro, Kraven, Sandman, the Vulture, and Mysterio. Together they have kidnapped Aunt May and Betty Brant to use as bait for Spider-man. Meanwhile Peter Parker has lost his powers and without them how can he defeat the Sinister Six?!
The mechanical arms of Dr. Octopus are put on display. Octavious uses this to his advantage and gains control of his appendages, allowing his premature escape from incarceration, and allowing his criminal activities to resume.
Hammerhead mastermind's a crime wave in New York City, while meanwhile Doctor Octopus and Aunt May are making plans for the future that will shock Spider-Man. Special Bonus: the Spider-Mobile gets its first operational test!