The global madness has escalated and the Man-Thing is its latest victim. As Jennifer's grandfather looks to a story from the past for the answer to their current plight, she and the Man-Thing must traverse the boundaries of both time and space if they are to put a stop to the chaos.
Hundreds of years ago, an African slave named N'Kantu rallied his comrades and challenged the rule of Nephrus and Aram-Set. The uprising saved N'Kantu from a life of slavery and prejudice, but it also prevented his death... forever.
With the Thing and Medusa captured only Reed now stands to defend the Baxter Building from the Frightful Four. But who is Thundra, the newest member of this sinister cohort, and what are her true motives? Meanwhile, Johnny Storm finds that things are not as they seem in the Great Refuge.
The mysterious Omega has captured Crystal and is confronted by Johnny and Pietro while the rest of the Great Refuge waits with bated breath. What is the source of power for this maleficent being and can our heroes discover it in time?