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The issue opens with us learning about the home of the Norse Gods, Asgard, and more specifically Loki, who is the God of Mischief. Loki had been trapped by the other Gods in a tree, where he was to remain until his plight caused someone to shed a tear. Having been trapped for centuries in the tree, Loki had gained control over it and commanded a leaf to break off and fall into the eye of Heimdall, who happened to be passing by. This caused Heimdall to shed a tear and Loki was set free, vowing to get revenge on the one most responsible for his capture... Thor!

Loki uses his magic to locate Thor, discovering that he is on Earth entertaining children in a hospital. Loki makes his way to Earth and disguises himself so as not to stand out. Reaching the hospital, Loki discovers that Thor had left and had no idea where he was, and not wanting to attract attention onto himself decides to create a disturbance that would bring Thor to him.

On the way back from a house call, Dr. Don Blake and his nurse Jane Foster hear cries of help. The see several people who had been turned into negatives of themselves. Dr. Blake runs into an alley where he is unseen as he transforms himself into Thor. He then makes his way to the negative people in need.

By spinning his hammer very fast in his hand, like a top, Thor is able to create anti-matter particles and blow them over to the negative people causing them to transform back into positive people. The crowd of onlookers cheer for Thor as Loki in disguise makes his to Thor. Thor doesn't recognize Loki so he sheds his disguise, which jars Thor's memory.

Loki challenges Thor to battle, with Jane thinking of how lovely Loki's name is and how dashing and romantic he seems. Loki uses his magic to make a carpet begin to fly so that they can battle in the air. Thor follows Loki into the air by spinning his hammer overhead, which causes the sun to reflect back into his eyes each time it passes. Loki uses this to hypnotize Thor and put him under his control.

Loki commands Thor back to Earth so that he can use him to cause mischief, but he realizes that if Thor were to be snapped out of the trance and had his hammer, that he would be no match for Thor. So he orders Thor to give him the hammer, but since the Hammer belongs only to Thor, he would not release it. Loki then tries to have Thor throw the hammer away in a lake by telling him that a sea beast is attacking. Thor throws the hammer into the lake, but then returns right to him. Loki next conjures up another Thor and tricks the real Thor into giving the hammer to the image.

Having succeeded in getting the hammer away from Thor, Loki orders him to release the animals from a nearby zoo. Loki is then distracted by a group of people who are trying to lift Thor's hammer. While Loki is distracted, Thor transforms back into Dr. Blake and is set free of the hypnotic spell. Dr. Blake manages to reach the Hammer and transform back into Thor in order to finish the fight against Loki.

Loki uses his magic to gather the pigeons in the area to him so that he can make his escape, but Thor hurls his hammer at Loki while hanging on to fly at him. This forces Loki to land and take cover in a crowded theater. Loki taunts Thor up onto the stage and uses his magic to bring the curtains down onto Thor, trapping him momentarily. Thor blows the curtain off of him and resumes his battle.

Loki runs into a subway station and throws several people onto the tracks with a train fast approaching. Thor rushes onto the tracks and bends them so that the train goes right over the people without harming them. With the innocent saved, Thor chases after Loki again and spots him in the air, but with so many people around, Thor is unable to spin his hammer to follow him.

With Thor unable to follow him, Loki takes to damaging store display for pure enjoyment, but quickly grows tired of it. Thor spots an opening when finds large sections of pipe and hurls one at Loki. Trapped in the pipe, Loki falls into the water, where his magic is useless, and is rescued by Thor. With Loki still wet, Thor takes him to the Empire State Building and hurls his hammer with Loki attached back to Asgard.