Minor suggestions--by no means essential.
I think Thor #182-183 should be moved to occur sometime before Sub-Mariner #47-49. I think Doom's quest and failure for a solution to his deformed face via surgery with Dr. Blake (T182-183) is good set up material detailing some of his motivation to find the Cosmic Cube (SM 47-49) and it would break up a little of the "Thor-a-palooza" from CMRO #1164-1191. There are plenty of places these two issues could be moved. Maybe between Frankenstein #4 and Tomb of Dracula #1? There's really no reason those two have to go together and it might break up the horror run a little, which for me was kind of a shocking change of pace--although now that I'm geeting used to them a bit, I may back off my thought of skipping them.
Again, not essential.
Another topic--Monsters on the Prowl #11 is nothing but annoying. I know they "shoe-horned" it in to mainstream continuity, but it clearly was not intended as such when it was written. It is case-in-point for a "Supplemental Reading" list--stuff that is really not part of the MU, but could be construed as having a tenuous tie-in. I'm also thinking the "Femizon" story from Savage Tales #1 would fall in this category as well.
Just my two cents.
Moved the Thor issues. On the other 2, yea they are a bit annoying, but the Monsters on the prowl at least, is referenced several times and while a bad read is in. Single issues that are marginal, I am thinking are fine to be in. Its the whole runs that I was thinking to keep out. Specific, where the entirety of events are set pre-ff #1 more or less (not mini-series, but whole runs). That was my general thinking at least.