Doctor Otto Octavious, a brilliant atomic scientist, is caught in an explosion when one of his experiments goes wrong, causing his brain damage and the mechanical arm apparatus he was wearing to fuse to his vertebrae. The demented Doctor still strives to carry on with his experiments and no one will stop him. Not even Spider-man!
Flint Marko, an escapee from a maximum security prison and on the FBI's most wanted list, has started to rob banks. Spider-man stands in his way but soon discovers that there is a reason Flint is known as the Sandman!
Dr. Doom seeks an ally and believes that Spider-Man's strength combined with his could defeat the Fantastic Four forever. Naturally he is turned down by our hero but Dr. Doom teaches Spider-man that to not be with him is to be against him.
In the swamps of Florida, a creature has appeared and is terrorizing the local inhabitants. The Bugle has issued a provocation on Spider-man to defeat this abomination and so Peter Parker finds himself traveling to Florida. Where Spider-man will face off against the Lizard!
Max Dillon was an ordinary electric pole-man when a lightning bolt struck him, giving him the power to generate electricity from his own body! Now as Electro nothing can stop him from taking anything he wants except the amazing Spider-man!
Doctor Octopus escaped from Spider-man in Philadelphia and has been on a crime spree ever since. Finally returning to New York to confront his nemesis, he kidnaps Betty Brant and uses her as bait to get a confrontation with the amazing Spider-man!
Now that Aunt May is feeling better, Peter Parker is free to act as Spider-man once again! The Enforcers and Sandman have captured the Human Torch and plan to use him as bait to defeat Spider-man once and for all!
Peter becomes aware of the cameras monitoring him and devises a plan to protect his identity. Meanwhile, Smyth prepares to get in bed with the major crime bosses of New York, but before a deal can be reached he must defeat Spider-Man.
Smythe brings a helpless Spider-Man back to his headquarters where the top crime bosses await him. They agree to go along with Smythe's plan and pull a bank heist with him directing their escape route. Flash apologizes to Gwen as the mystery surrounding him deepens.
Aunt May has decided to stay on at Doc Ock's mansion, but before Peter has time to dwell on it his attentions are grabbed by the Smasher. Meanwhile, the rest of the city has come down with campaign fever, but who is Richard Raleigh, the charismatic frontrunner.
The election is about to get underway and Spider-Man must do his best to keep the Smasher and the Disruptor from tearing down the city. Will Richard Raleigh be the next mayor of New York or will the underworld destroy him first?
After a run in with the Werewolf, Peter Parker looks up DD and the Widow to get his interview for the Bugle. However, they hardly have time to finish their introductions before a Juggernaut wannabe makes the scene.
While Peter tries his best to keep his spirits up and his life in order, news of a new vigilante hits the city. Jameson sends Peter to get photos of the Punisher but, as it turns out, the Punisher is looking for him too and he wants more than photos.
After what seems like months of constant action Peter settles in for a nice afternoon with his friends. Of course, trouble is never far from old Spidey and this time around trouble goes by the name Tarantula.