Peter explores and experiments with his new-found abilities as they continue to manifest and evolve. Meanwhile, the sinister forces at OzCorp are monitoring the teenager's every move, and generate a dastardly plan to learn even more...
Peter begins to exploit his skills for financial gain, as those who know his secret, push forward to unlock its potential. Can Peter continue to juggle his new powers with his love life and academics, or is he pushing too far?
In response to mutant terrorist attacks, the U.S. government has begun a program to eradicate all mutants. In response, Charles Xavier gathers together a group of young mutants in a desperate gambit to improve relations between humans and mutants before events escalate into all out war.
Spider-Man becomes the newest target for the television sensation, Kraven the Hunter. Meanwhile, Doctor Otto Octavious, with the aid of his new mechanical limbs, seek revenge against Justin Hammer for an unknown reason.
Norman orders Peter to quit being Spider-Man and work for him. As Peter tries to deal with Norman's knowledge of his secret identity, Gwen comes over in the middle of the night, leaving Mary Jane feeling left on the outside.